| ncRNA name | TNFα siRNA |
| ncRNA Category | siRNA |
| Disease name | diabetic retinopathy (DR) |
| Species | Homo sapiens |
| Tissues/Cell_line | human retinal endothelial cells (HRECs) |
| Methods | siRNA transfection, Western blot, ELISA |
| Expression pattern | associated |
| Functional description | Knockdown of TNFα leads to decreased phosphorylation of IRS-1(Ser307), which would promote normal insulin signaling. Knockdown of SOCS3 increased total IRS-1 levels, as well as decreased IR(Tyr960), both of which would inhibit retinal endothelial cell apoptosis through increased insulin signaling. |
| PubMed ID | 22266116 |
| Year | 2012 |
| Title | TNFα and SOCS3 regulate IRS-1 to increase retinal endothelial cell apoptosis. |
| Drug-related ncRNA | NO |
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